Glycine Injection

Glycine is, structurally, the simplest amino acid that has been discovered. It was one of the earliest amino acids to be isolated from gelatin back in 1820. Glycine is one of the nonessential amino acids for mammals; meaning that they can create it internally from two other amino acids: serine and threonine.

Glycine is found principally in gelatin and silk fibroin. It’s been used therapeutically as a nutrient, and also functions as a rapid inhibitory neurotransmitter in the central nervous system (CNS). Although glycine is both a simple and nonessential amino acid; experimental animals on low-glycine diets show reduced growth. The average adult will ingest 3 to 5 grams of glycine daily from dietary sources.  Glycine is an amino acid that’s involved in the production of DNA, phospholipids, and collagen. It’s also involved in the release of energy.

Joint Repair: Glycine plays a vital role in collagen formation. It’s an important component for promoting joint, tendon, and ligament function and growth. Roughly 1/3 of collagen in the body is composed of glycine, and collagen is critical for the formation of the connective tissues that keep joints flexible and capable of successfully withstanding shocks.

Muscle Growth: The body uses glycine during the biosynthesis of creatine; which supplies all muscles with a source of fuel to repair damage and grow stronger. It also provides cells with energy due to its role in converting dietary nutrient to help feed muscle tissues and may potentially boost:

• Endurance
• Strength
• Performance

Glycine also benefits hormone production and regulation. It helps the body to naturally synthesize steroid hormones essential to regulating both the fat to muscle ratio and control energy expenditure.

Anxiety: Glycine will work with other amino acids, including taurine and gamma-amino butyric acid (GABA), to act as an inhibitory neurotransmitter. This role in nerve and neurotransmitter functions has implications for improving; sleep quality, mental performance, moods, memory, and behavior. Some evidence suggests that glycine may help reduce hyperactivity in the brain and play an effective role in the treatment and prevention of certain mental disorders, such as learning disabilities, schizophrenia, bipolar disorder, and epilepsy. Other studies have demonstrated that glycine can help minimize psychotic symptoms and seizures when used with other supplements as part of a treatment plan for neurological illness.

Digestion: Amino acids, including glycine, help to rebuild the tissue that lines the digestive tract; keeping bacteria and food particles contained inside the gut, rather than exiting through tiny openings that pass this matter into the bloodstream where it can trigger an inflammatory response Glycine plays a role in forming the two most important substances in the gut lining: collagen and gelatin.

Inside the GI tract; glycine will be utilized as a metabolic fuel. It’s required in the production of bile (to break down fats), nucleic acids, creatine phosphate and the porphyrins used to break down nutrients. It helps move glycogen to the cells for the production of ATP for energy. Studies show that glycine may help stabilize blood sugar levels, preventing food cravings and fatigue.

Aging: Glycine is used to produce glutathione, an antioxidant that prevents cell damage and several signs of aging. A paper published in the American Journal of Clinical Nutrition concluded that; while glutathione deficiency in the elderly occurs because of a distinct reduction in glutathione synthesis; supplementing the diet with the glutathione precursors cysteine and glycine can restore normal glutathione production.

7-keto-DHEA is believed promote weight maintenance or loss by increasing resting metabolic rate.17 On a molecular level, studies in preclinical animal models showed that 7-keto-DHEA increased the activity of enzymes involved in thermogenesis, including mitochondrial and cytosolic sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme. It also increased the rate of mitochondrial substrate oxidation and the activity of enzymes involved in fatty acid oxidation, including liver catalase and fatty acyl-CoA oxidase.18 It is unknown how 7-keto-DHEA mediates these changes; however, it is believed the metabolites of 7-keto-DHEA, 7α-OH-DHEA and 7β-OH-DHEA, may be involved.318

Other effects of DHEA and 7-keto-DHEA, such as increased immune response, may also be mediated by 7α-OH-DHEA and 7β-OH-DHEA.23 Both 7α-OH-DHEA and 7β-OH-DHEA have been shown to inhibit the reduction of cortisone to cortisol in human skin; however, 7β-OH-DHEA was seven times more potent than 7α-OH-DHEA. Thus, it is possible that part of the physiological activity of 7-keto-DHEA and its metabolites is mediated by their ability to act as anti-glucocorticoids.19 However, given that cortisone and cortisol are present in substantially higher levels than 7α-OH-DHEA and 7β-OH-DHEA, these 7-keto-DHEA metabolites may not have a systemic effect, but they may act locally in tissues through autocrine or paracrine processes.

People being treated with clozapine should avoid taking glycine.

A small number of individuals have reported experiencing slight sedation after using glycine.

Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

Learn how to prepare medication for self-administered injection.

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16.Li, Changhong et al. “Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by Γ-Hydroxybutyrate and Glycine.” The Journal of Biological Chemistry 288.6 (2013): 3938–3951. PMC. Web. 6 Oct. 2017.
17.Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Clin Nutr. 2011 Sep;94(3):847-53. doi: 10.3945/ajcn.110.003483. Epub 2011 Jul 27.
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19.Gusev EI, Skvortsova VI, Dambinova SA, Raevs